In 1990 members of the Romanian Royal Family established “Princess Margarita of Romania Foundation – Switzerland” in order to assist in the reconstruction of Romania's social infrastructure. The Foundation set up an operations office in Bucharest and four fundraising entities subsequently emerged in Belgium, France, the UK and the US.

As a result of strategic restructuring, in August 1998, Her Royal Highness The Princess Margarita of Romania established “Princess Margarita of Romania Foundation – Romania” (PMRF-R) as a separate entity under the Romanian law, with a mandate to develop and implement projects in the fields of welfare for children, youth and the elderly, community health care and health promotion, culture, education, and the development of civil society.

Princess Margarita of Romania Foundation-Romania now devotes more than 70 percent of its budget to programs targeting youth and children. Recently, PMRF-R started a grant program for NGOs dealing with children and youth at risk. Additionally, Princess Margarita of Romania Foundation-Romania runs a nutrition program for HIV infected children, and gives emergency help to other children in need – hereby responding to the specific situation of the country. The Foundation also pioneers an art-therapy program for children in institutions (most of them being abandoned children and representing the highest percentage of abandoned children in the region). Moreover, in 1994 the Foundation began a program to support emerging artists at a high school in Bucharest. That initiative is now being developed into the "Trust/Confidence Fellowship for Young Artists".